Table 2.
Literature review
| Study number | Authors | Presenting symptoms | Treatment | Outcome |
| 1 | Smallridge et al5 | Asymptomatic. | DES. Bilateral orchidectomy. TURP. ERT. Cyclophosphamide. 5-FU. |
Radiological progression of metastatic disease. |
| 2 | Szentirmai et al6 | Lethargy. | None. | Died in 2 weeks. |
| 3 | Tandon and Rizvi7 | Unknown. | Goserelin. Leuprolide. |
Hypocalcaemic on discharge. |
| 4 | Fokkema et al8 | Lethargy. | Leuprorelin. Bicalutamide. |
Died in 4 months. |
| 5 | Rizzo et al9 | Lethargy. | ADT. | Died in 2 months. |
| 6 | Pusulari et al10 | Back pain and fatigue. | None. | Unknown. |
| 7 | Yener et al11 | Tetany and anorexia. | TURP. Goserelin. Bicalutamide. |
Eucalcaemic after 12 weeks. |
| 8 | Riveros et al12 | Bone pain. | ADT. Docetaxel. Mitoxantrone. Abiraterone. Zoledronic acid. |
Died in 3 weeks. |
| 9 | Lim et al13 | Seizures. | Calcitriol. | Unknown. |
| 10 | Kabadi15 | Back pain. | Prostate resection. Bilateral orchidectomy. DES. ERT. |
Calcium and phosphorous normalised. |
| 11 | Kukreja et al14 | Not mentioned. | Calcium and magnesium supplementation. | Unknown. |
5-FU, 5-flourouracil; ADT, androgen deprivation therapy; DES, diethylstilbestrol; ERT, external radiotherapy; TURP, transurethral resection of prostate.