(A-C) Kaplan-Meier plots of patients with (A) CD8-high versus CD8-low stage II and III disease in the Colorectal Cancer Intrinsic Subtype (CRIS) -C surgery-only, taxonomy cohort; (B) CD3-high versus CD3-low stage II and III disease in the CRIS-C surgery-only, taxonomy cohort; and (C) CD8-high versus CD8-low stage II disease in the CRIS-C surgery-only, taxonomy cohort. Patients were split into high (blue) and low (gold) CD8 or CD3 groups using the median as cutoff. Significance was assessed using a log-rank test. (D) Diagram of a potential decision tree for treatment of patients with stage II disease in the CRIS-C cohort. CMS2, consensus molecular subtype 2; FU, fluorouracil; IHC, immunohistochemistry.