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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Science. 2018 Feb 16;359(6377):787–790. doi: 10.1126/science.aan4074

Fig. 4. Chronically epileptic mice have impaired OLM but not ORM, and MC inhibition impairs learning but not retrieval of OLM.

Fig. 4

(A) OLM test schematic and timeline. Epileptic mice (n = 17) exhibit significantly impaired OLM, compared with nonepileptic controls (n = 13). (B) ORM test schematic and timeline. Nonepileptic (n = 10) and epileptic (n = 14) mice show no significant difference in ORM. (C) MC photoinhibition during learning interferes with OLM (dorsal: n = 9|10; ventral: n = 8|5 for eYFP|eNpHR). (D) MC photoinhibition during testing does not interfere with OLM (dorsal: n = 9|8; ventral: n = 6|7 for eYFP|eNpHR). (E and F) MC photoinhibition during ORM learning does not impair task performance (dorsal: n = 10|9; ventral: n = 9|10 for eYFP|eNpHR). (F) MC photoinhibition during ORM testing does not affect task performance (dorsal: n = 10|10; ventral: n = 7|9 for eYFP|eNpHR). Data are presented as mean ± SEM. *P < 0.05; two-tailed Welch’s t test.