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. Author manuscript; available in PMC: 2018 Dec 6.
Published in final edited form as: J Am Chem Soc. 2017 Nov 20;139(48):17253–17256. doi: 10.1021/jacs.7b09223

Figure 2.

Figure 2.

(A) Relationship between ΔGb of H3K9me3/HP1-UAA variant interactions and calculated gas-phase cation–π binding energies between C6H5R and Na+.10 Y24 mutants (blue): slope = −0.074, R2 = 0.94; Y48 mutants (red): slope = −0.048, R2 = 0.93. (B) Relationship between ΔGb and calculated polarizability.29 (C) Relationship between ΔGb and hydrophobicity parameter (log P). In each panel, the two data sets share the wild type (WT) point shown in black.