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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Curr Opin Oncol. 2015 May;27(3):172–176. doi: 10.1097/CCO.0000000000000178

FIGURE 1.

FIGURE 1

A. Siah2 ubiquitinates and degrades the AR-NCOR1 complex on AREs of select AR targets. This allows the subsequent recruitment of AR-p300 to activate the transcription of these AR targets. B. RNF6 induces the atypical ubiquitination of AR, and this causes the recruitment of co-activators that have the ubiquitin-binding domain. The AR/co-activator complex binds to AREs of selective AR targets and increases the transcription of these AR targets. C. wild-type (wt) SPOP interacts with AR, leading to the ubiquitination and degradation of AR by the Cul3-Rbx1 ubiquitin ligase complex. Mutant (mut) SPOP cannot interact with AR, resulting in the stabilization of AR and increase of global AR target expression.