Table 1.

Association of SNP within SYNJ1 Gene with Age at Onset and Memory Scores in a Cohort of Caribbean Hispanic Families with the PSEN1-G206A Mutation

		Age at Onseta		Global Memoryb		Long-Term Recallb		Delayed Recallb
SNP	Location (bp)	Beta	p Value	Beta	p Value	Beta	p Value	Beta	p Value
21:34004976	34,004,976	−0.77	0.6602	5.90	0.0397c	6.81	0.0083c	1.04	0.0504
21:34006054:G:T	34,006,054	14.91	0.0094c	9.88	0.3092	5.71	0.5150	1.45	0.4203
21:34012999	34,012,999	0.22	0.8909	6.46	0.0137c	7.14	0.0024c	1.10	0.0230c
21:34019201	34,019,201	−16.14	0.0061c	7.06	0.5553	6.84	0.5278	3.00	0.1862
21:34041167	34,041,167	−10.23	0.0010c	2.94	0.6074	1.23	0.8125	−0.21	0.8402
rs200644223:34057206: ACGGCCGGG:A	34,057,206–34,057,214	−0.98	0.7395	−15.13	0.0004c	−11.55	0.0029c	−2.14	0.0066c
21:34078985	34,078,985	22.46	0.0050c	−0.09	0.9939	−4.05	0.7115	2.39	0.2821

See also Figure S2 and Tables S1 and S2 for additional information.

^aCovariates included AD, sex, PSEN1-G206A, education, APOE4, and principal components (PC1, PC2, and PC3). Age at onset is defined as age at onset for affected individuals and age at last examination for unaffected individuals (see text for details).

^bCovariates included age at onset, sex, education, APOE4, and principal components (PC1, PC2, and PC3).

^cp < 0.05.