Table 2.

Sliding-Window Haplotype Analysis of SYNJ1 Gene in Late-Onset FAD (EFIGA)

rs11702774	rs2833930	rs2833931	rs10470165	rs17694546	rs2833934	rs2833935		Model 1	Model 2	H1/H1		H1/−		−/−
A/G(a)	A/G	A/G	G/A	A/C	A/G	G/A	Haplotype	p Valueb	p Valuec	Mean	SD	Mean	SD	Mean	SD
Window1							GAA	0.1145	0.1019	67.9	10.5	70.7	9.8	71.2	9.8
	Window2						AAA	0.2072	0.1828	69.8	10.4	71.1	9.8	71.2	9.7
		Window3					AAA	0.0709	0.0580	80.0	1.4	72.4	10.7	71.0	9.8
			Window4				AAG	0.0709	0.0580	80.0	1.4	72.4	10.7	71.0	9.8
				Window5			AGA	0.0418d	0.0342d	80.0	1.4	72.5	10.7	70.7	9.8
Window1							GAAA	0.1184	0.1059	67.9	10.5	70.7	9.8	71.2	9.8
	Window2						AAAC	0.3410	0.2979	70.4	10.3	71.0	9.8	71.2	9.7
		Window3					AAAG	0.0714	0.0584	80.0	1.4	72.4	10.7	71.0	9.8
			Window4				AAGA	0.0323d	0.0256d	80.0	1.4	72.4	10.7	70.7	9.8

See also Figure S1 and Tables S1 and S3 for additional information.

^aA minor allele is presented first.

^bCovariates for model 1: Alzheimer’s disease, sex, education, APOE4, principal components (PCs), and genetic relationship matrix (GRM).

^cCovariates for model 2: similar to model 1 but excludes APOE4.

^dp < 0.05.