Table 3.

Association of Year 14 HR-pQCT microarchitectural parameters with history of prior major osteoporotic fracture between MrOS baseline and Year 14 study visits, Odds Ratio (95% CI)

	Per 1 SD decrease unit	Model 1	Model 2	Model 3
Distal Radius		n-used=1702	n-used=1657	n-used=1639
		n-event=104	n-event=98	n-event=98

FEA estimated failure load, N	1338.1 N	1.74 (1.38, 2.20)	1.44 (1.09, 1.90)	1.43 (1.08, 1.90)
Total vBMD, mg/cm³	61.2 mg/cm³	1.82 (1.45, 2.30)	1.54 (1.17, 2.02)	1.49 (1.12, 1.96)
Total bone area, mm²	66.3 mm²	0.76 (0.61, 0.94)	0.75 (0.60, 0.93)	0.78 (0.62, 0.99)
Trabecular vBMD, mg/cm³	39.4 mg/cm³	1.88 (1.50, 2.35)	1.65 (1.26, 2.14)	1.61 (1.23, 2.11)
Trabecular number, mm⁻¹	0.21 mm⁻¹	1.75 (1.44, 2.13)	1.53 (1.21, 1.93)	1.52 (1.20, 1.92)
Trabecular thickness, mm	0.018 mm	1.20 (0.97, 1.48)	1.09 (0.87, 1.36)	1.06 (0.84, 1.34)
Trabecular bone area, mm²	68.3 mm²	0.71 (0.58, 0.88)	0.74 (0.59, 0.92)	0.77 (0.61, 0.98)
Cortical vBMD, mg/cm³	69.2 mg/cm³	1.34 (1.10, 1.63)	1.16 (0.94, 1.44)	1.13 (0.91, 1.41)
Cortical porosity, %	0.81%	1.46 (1.16, 1.85)	1.37 (1.08, 1.75)	1.38 (1.08, 1.76)
Cortical thickness, mm	0.230 mm	1.56 (1.24, 1.95)	1.32 (1.03, 1.70)	1.28 (0.99, 1.66)
Cortical bone area, mm²	14.3 mm²	1.40 (1.12, 1.76)	1.13 (0.88, 1.46)	1.13 (0.87, 1.47)

Distal Tibia		n-used=1717	n-used=1678	n-used=1660
		n-event=115	n-event=109	n-event=109

FEA estimated failure load, N	2934.3 N	1.94 (1.55, 2.42)	1.51 (1.13, 2.02)	1.50 (1.11, 2.01)
Total vBMD, mg/cm³	55.2 mg/cm³	1.89 (1.52, 2.36)	1.47 (1.11, 1.94)	1.38 (1.04, 1.82)
Total bone area, mm²	136.9 mm²	0.78 (0.63, 0.98)	0.77 (0.61, 0.98)	0.80 (0.63, 1.03)
Trabecular vBMD, mg/cm³	38.1 mg/cm³	1.53 (1.25, 1.88)	1.16 (0.91, 1.48)	1.10 (0.86, 1.41)
Trabecular number, mm⁻¹	0.213 mm⁻¹	1.19 (0.98, 1.44)	0.89 (0.71, 1.11)	0.86 (0.69, 1.08)
Trabecular thickness, mm	0.023 mm	1.20 (0.98, 1.47)	1.07 (0.86, 1.32)	1.03 (0.83, 1.29)
Trabecular bone area, mm²	145.7 mm²	0.69 (0.55, 0.87)	0.74 (0.59, 0.94)	0.77 (0.60, 0.98)
Cortical vBMD, mg/cm³	80.8 mg/cm³	1.49 (1.23, 1.81)	1.23 (0.99, 1.53)	1.21 (0.96, 1.51)
Cortical porosity, %	1.65%	1.14 (0.93, 1.39)	1.12 (0.92, 1.37)	1.15 (0.93, 1.41)
Cortical thickness, mm	0.335 mm	1.74 (1.40, 2.15)	1.40 (1.09, 1.78)	1.38 (1.08, 1.77)
Cortical bone area, mm²	31.1 mm²	1.63 (1.34, 2.01)	1.30 (1.03, 1.65)	1.31 (1.03, 1.68)

Diaphyseal Tibia		n-used=1499	n-used=1465	n-used=1449
		n-event=98	n-event=92	n-event=92

FEA estimated failure load, N	2703.3 N	1.60 (1.27, 2.00)	1.23 (0.94, 1.62)	1.25 (0.94, 1.65)
Total vBMD, mg/cm³	78.6 mg/cm³	1.19 (0.97, 1.46)	0.88 (0.69, 1.12)	0.83 (0.64, 1.06)
Total bone area, mm²	51.7 mm²	1.35 (1.07, 1.71)	1.28 (1.00, 1.64)	1.42 (1.09, 1.86)
Cortical vBMD, mg/cm³	35.0 mg/cm³	1.12 (0.91, 1.37)	0.95 (0.77, 1.19)	0.88 (0.70, 1.12)
Cortical porosity, %	1.18%	0.87 (0.72, 1.04)	0.98 (0.80, 1.19)	1.02 (0.84, 1.26)
Cortical thickness, mm	0.881 mm	1.27 (1.03, 1.57)	0.93 (0.72, 1.21)	0.92 (0.71, 1.19)
Cortical bone area, mm²	40.3 mm²	1.54 (1.22, 1.93)	1.20 (0.91, 1.57)	1.23 (0.93, 1.63)

Model 1 adjusted for V4 age, race, limb length and clinic site

Model 2 adjusted for V4 age, race, limb length, clinic site and V4 total hip BMD

Model 3 adjusted for V4 age, race, clinic site, limb length, weight, physical activity, baseline smoking status, alcohol consumption, past falls, self-reported history of fracture between age 50 and MrOS baseline, and V4 total hip BMD