Table 2.
Factors associated with the risk of HCC
| Univariate | Multivariate-1 | Multivariate-2 a | ||||
|---|---|---|---|---|---|---|
| Age (10 years) | 1.1 (0.9–1.4) | 0.21 | 1.4 (1.1–1.8) | 0.02 | 1.4 (1.1–1.9) | 0.02 |
| Male | 1.7 (1.1–3.0) | 0.03 | 1.2 (0.7–2.1) | 0.59 | 1.1 (0.7–2.0) | 0.67 |
| Non Caucasian Race | 1.9 (1.0–3.4) | 0.06 | 1.0 (0.4–2.0) | 0.93 | 1.1 (0.5–2.2) | 0.88 |
| Etiology | ||||||
| Other (Reference) | – | – | – | – | – | – |
| HCV | 6.4 (2.9–17.1) | <0.01 | 6.1 (2.5–17.0) | <0.01 | 8.5 (3.4–25.0) | <0.01 |
| HBV | 6.2 (1.3–23.5) | 0.03 | 5.0 (0.7–26.5) | 0.11 | 4.1 (0.5–21.8) | 0.16 |
| Alcohol | 2.0 (0.8–5.6) | 0.12 | 1.6 (0.6–4.5) | 0.33 | 1.5 (0.6–4.3) | 0.37 |
| NAFLD | 1.9 (0.8–5.6) | 0.17 | 1.4 (0.5–4.3) | 0.49 | 1.1 (0.4–3.3) | 0.91 |
| BMI | 1.0 (1.0–1.0) | 0.74 | ||||
| CTP | 1.0 (0.8–1.2) | 0.99 | ||||
| MELD (per 5 unit) | 1.1 (0.8–1.3) | 0.60 | ||||
| Diabetes | 1.4 (0.8–2.2) | 0.23 | 1.1 (0.6–1.9) | 0.68 | 2.0 (0.9–4.2) | 0.08 |
| Albumin | 0.5 (0.4–0.8) | <0.01 | 0.5 (0.4–0.8) | <0.01 | 0.5 (0.4–0.7) | <0.01 |
| International normalized ratio | 1.1 (0.7–1.6) | 0.54 | ||||
| Creatinine | 0.9 (0.5–1.2) | 0.51 | ||||
| Bilirubin | 1.0 (0.9–1.0) | 0.54 | ||||
| Diabetes a HCV | 0.3 (0.1–0.9) | 0.03 | ||||
BMI, body mass index; CTP, Child Turcotte Pugh; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; MELD, Model for End-stage Liver Disease.
a
Multivariate model 2 included an interaction term of HCV and diabetes.