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. 2018 Jul 11;4(7):eaat2624. doi: 10.1126/sciadv.aat2624

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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Fig. 4 — (A) Distribution of CpG methylation in embryonic liver, stratified by methylation level in ICM. Horizontal lines show the median methylation in embryonic liver. Error bars represent 95% bootstrapped confidence intervals. (B) Change in methylation at individual CpGs across the transition. Each line represents the change in methylation at a CpG for a single combination of replicates from each stage. *Because of the large number of data points, “all-RRBS” plot shows a random 0.1% sample of all possible ICM–embryonic liver transitions. (C) Distribution of methylation states in each embryonic liver replicate.