Table 1 |. Transgenic models of cancer in the zebrafish.

Cancer	Oncogene	Tumour suppressor	Use in cancer biology	Refs
Melanoma	mitfa–BRAFV600E	tp53−/−	Genetic and chemical modifier screens	27, 30,31
	mitfa:EGFP:NRASQ61K	tp53−/−
	kita–Gal4 × uas-HRAS
Pancreatic	ptf1a–KRASG12V–GFP		Genetic modifier screens	22,97
	ptf1a:Gal4–VP16 × uas–KRASG12V–GFP
T cell lymphoma or	rag2–myc		Cancer modelling and in vivo imaging	14,98
leukaemia	rag2–lox–dsRED2–lox–EGFP– mMyc × hsp70–cre		Inducible cancer model	99
	rag2–NOTCH1		NOTCH1 interaction with Bcl‑2	100,101
	rag2–myc × rag2–bcl2		Mechanisms of leukaemia dissemination	39
B cell leukaemia	Xenopus Spp. EF1α or zebrafish B actin– TEL–AML1 (ETV6–RUNX1)		Initiating events in B cell leukaemia	34
Numerous	b‑actin–lox–GFP–lox–KRASG12D × hsp70–cre		Inducible cancer model	102
	krt4:Gal4VP16;14 × uas:smoa1–		Cooperation of hedgehog and AKT pathways	103
Rhabdomyosarcoma	rag2–KRASG12D		Identification of tumour-initiating cell populations	29
Neuroblastoma	dβh:EGFP–MYCN		Cooperation of MYCN and ALK	23
	dβh:EGFP and dβh:ALKF1174L		Cooperation of MYCN and ALK	23
AML	pu1–MYST3/NCOA2–EGFP		First model of AML in zebrafish	104
MPNST		tp53−/−	Conservation of tumour-suppressor pathways in zebrafish	17
			Major tumour type found in p53‑deficient zebrafish
Lipoma	krt4–myrAKT1		Platform for the study of drugs to treat lipoma and/or obesity	105
Ewing’s sarcoma	hsp70 or β-actin–EWSR1–FLI1	tp53−/−	Conserved function of EWS–FLI1 fusion protein from human to fish	106
Liver	fabp10:LexPR; LexA:EGFP × cryB:mCherry; LexA:EGFP–krasG12V		Inducible KRAS‑G12V hepatocellular cancer model	36
	fabp10:TA; TRE:xmrk; krt4:GFP		Inducible EGFR-homologue hepatocellular cancer model	107
Pancreatic neuroendocrine	zmyod–MYCN		Pancreatic neuroendocrine model as a platform for downstream MYCN targets	108
Myeloproliferative neoplasms	sp1–NUP98–HOXA9		NUP98–HOXA9‑induced oncogenesis from defects in haematopoiesis and aberrant DNA damage response	109
Corticotroph adenoma and neoplasm	POMC–PTTG		Identification of CDK inhibitors as possible treatment of corticotroph tumours	110
Testicular germ cell tumour	fugu flck–SV40 large T		Platform for modifier screens of testicular tumours	35

ALK, anaplastic lymphoma kinase; AML, acute myeloid leukaemia; CDK, cyclin-dependent kinase; EF1α, elongation factor 1α; EGFP, enhanced green fluorescent protein; fabp10, fatty acid-binding protein 10, liver basic; GFP, green fluorescent protein; hsp70, heat shock protein 70; krt4, keratin 4; mitfa, microphthalmia-associated transcription factor a; MPNST, malignant peripheral nerve sheath tumour; myr, myristoylated; POMC, pro-opiomelanocortin; ptf1a, pancreas transcription factor 1 subunit a; PTTG, pituitary tumour-transforming gene; rag2, recombination-activating gene 2; smoa1, activated smoothened mutant; uas, upstream activating sequence.