Table 3.

Randomized Controlled Trials of Geriatric Assessment Underway

Study	Design	Population	Intervention Delivery	Management Strategy	Outcomes
Hurria et al. -City of Hope	2:1 Patient randomization n=600	age 65+ with any stage solid tumor malignancies starting a new chemo regimen (any line)	Study NP in collaboration with the primary oncologist and clinic nurse	Established protocol for referral to the multidisciplinary team based on multidisciplinary team input and triggers based on GA results	4 Primary endpoints: Chemo toxicity (Gr3+); Rate of hospitalization; change in functional status; change in psychosocial status
Soubeyran et al.35 -28 Regional Coordination Units for Geriatric Oncology (mix of sites)	Patient randomization n=1200	age 70+ with most solid tumor malignancies candidate for first/second line medical treatment	Geriatrician with nurse follow up	Established protocol based on expert input	Co-primary endpoint of overall survival and dimensions of QoL; Response; PFS; other QoL; chemo tox, health care utilization
Puts et al. -multi-center study of centers in Canada	Patient randomization n=350	aged 70+ with most solid tumor malignancies starting first/second line chemotherapy	Geriatric oncology with nurse follow up	Established protocol based on Delphi consensus and guidelines	QoL; Cost-effectiveness; Function; Chemo tox; Satisfaction; Cancer tx changes; Survival
Mohile et al. -community oncology practices affiliated with University of Rochester NCORP Research Base	Cluster randomization by oncology practice GAP n=700 COACH n=528	aged 70+ with advanced solid tumor malignancies	GA summary results and recommendation given to oncology team	Established protocol based on Delphi consensus panel and guidelines	GAP: chemo toxicity (Gr3+), survival, function COACH: communication, satisfaction, patient and caregiver QoL; health care utilization