Table 1.

Genes altered >4-fold by NCS-382 (0.5 mM) in HepG2 cells.

Gene	Gene product	Function	Gene grouping	Change
CD36	CD36 Molecule	Involved in platelet activation, signaling and aggregation and metabolism	Steatosis	↓
HTRA4	High-Temperature Requirement Factor A4	Degrades misfolded secretory proteins	ER Stress & unfolded protein response	↑
SERPINA3	Serpin Family A Member 3	plasma protease inhibitor; deficiency has been associated with liver disease	Phospholipidosis	↓
SLC2A3	Glucose Transporter Type 3, Brain	Facilitative glucose transporter	Phospholipidosis	↓
SLC51A	OST-Alpha	Transports the major species of bile acids	Cholestasis	↓
TNFRSF1A	Tumor Necrosis Factor Receptor Superfamily, Member 1A	Activates NF-κB, mediates apoptosis, and functions as a regulator of inflammation	Apoptosis & Necrosis	↑