Table 2.
Comparative characteristics between tobramycin 40 and 100 mg/ml solutions
| Parameters | Tobramycin 40 mg/ml | Tobramycin 100 mg/ml |
|---|---|---|
| pH 88 | 6.88 | 6.99 |
| Viscosity (centipoise) | 1.58 | 2.12 |
| Duration of nebulisation (min) | ||
| Endotracheal tube | 7.88 ± 1.08 | 18.56 ± 2.36* |
| Tracheostomy tube | 12 ± 1.4 | 14.63 ± 1.14* |
| Dv10 (μm) | 1.0 ± 0.05 | 1.4 ± 0.04 |
| VMD (μm) | 1.8 ± 0.2 | 2.1 ± 0.08 |
| Dv95 (μm) | 5.7 ± 0.2 | 3.6 ± 0.8 |
| FPF (%) | 82.3 ± 6 | 99.44 ± 0.3* |
| Lung dose (mg) | 39.2 ± 1.1 | 132.7 ± 12.6* |
dv10 volume diameter under which 10% of the sample resides; VMD volume median diameter under which 50% of the particles resides; dv95 volume diameter under which 95% of the sample resides; FPF fine particle fraction (1–5 μm)
*p < 0.05