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. 2018 Jul 11;9:2682. doi: 10.1038/s41467-018-05087-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Utilization of the ILK–RhoT–TRAK axis for regulation of mitochondrial distribution in highly invasive breast cancer cells. a–c MCF7 cells were transfected with siRNAs targeting AMAP1, Arf6, PRKD2, or TRAK1. ILK (green), microtubules (red), and nuclei (blue) were fluorescently visualized by specific antibodies or dyes. Bar, 10 μm (a). Protein expression of TRAK1 was analyzed by western blotting (b). Mitochondria (green), microtubules (red), and nuclei (blue) were fluorescently visualized by specific antibodies or dyes. Bar, 20 μm (c). d–f MDA-MB-435s cells were transfected with siRNAs targeting AMAP1, Arf6, ILK, or TRAK1. Protein expression of AMAP1, Arf6, and ILK was analyzed by western blotting (d). TRAK1 expression was also examined separately (e). Mitochondria (green), microtubules (red), and nuclei (blue) were fluorescently visualized by specific antibodies or dyes. Bar, 20 μm (f)