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. 2018 Jul 11;8:10439. doi: 10.1038/s41598-018-28714-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Holoprosencephaly, spina bifida and cyclopia in the Zic2 mouse mutant. Representative images illustrating a wildtype E14.5 embryo (a,a1–a5) and a Zic2^A5/A5 embryo (b,b1–b5) at E14.5. Dashed red lines in a and b indicate the level of sections shown below. The mutant embryo exhibits alobar holoprosencephaly indicated by a lack of separation in forebrain structures (b1,b2), cyclopia (b3), spina bifida (b4,b5 arrows) and right pulmonary isomerism (b4). Abbreviations: V-D – ventral – dorsal; R-L – right – left; MO – medulla oblongata; SC – spinal cord; SCC – semi-circular canal; TG – trigeminal ganglion; TV – telencephalic vesicle; CS- corpus striatum; P – pinna; E – eye(s); L – lungs; Liv – liver; K – kidneys.