Table 1.
Number of protease expressing cells in articular cartilage of mice treated with Furin or antagonist α1-PDX.
| DMM | ||||
|---|---|---|---|---|
| Control | Vehicle | Furin | α1-PDX | |
| MMP-13 (%) | 2.03 ± 0.19 | 20.96 ± 8.49** | 4.96 ± 0.60° | 23.60 ± 0.14 |
| ADAMTS-4 (%) | 10.1 ± 0.25 | 86.30 ± 5.22** | 80.06 ± 6.77 | 81.06 ± 3.94 |
| ADAMTS-5 (%) | 15.8 ± 0.90 | 62.15 ± 5.86** | 57.56 ± 8.98 | 65.88 ± 6.64 |
The number of cells expressing MMP-13, ADAMTS-4 or ADAMTS-5 was revealed by immunohistochemistry and expressed as a percentage of total cells.
*vs control: * < 0.05, **p < 0.001; °vs vehicle: °p < 0.05.