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. 2018 Jul 11;8:10453. doi: 10.1038/s41598-018-28623-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Linkage intervals on chromosomes 3, 7 and 17. The genome-wide linkage analysis of the UBRS082 family was carried out by using either SNP 10 K array (Human Mapping 10 K 2.0; Affymetrix, USA) and SNP 1 M array (Genome-Wide Human SNP Array 6.0; Affymetrix, USA), and analyzed by using easyLINKAGE software, set as autosomal dominant model in multi-point parametric mode (the analyses in other modes are not shown). The regions with high log of odd (LOD) scores on chromosomes 3, (Max LOD = 3.75), chromosome 7 (Max LOD = 3.01), and chromosome 17 (Max LOD = 2.98) were located.