Fig. 8.

Model to explain regulation of TFEB subcellular localization. a Summary of key regulatory phosphorylation events and their impact on TFEB subcellular location. b Model to explain the potential regulation of TFEB when amino acids or glucose are limiting. Under these conditions increased phosphatase activity targeting S211, and likely other phosphorylation sites, will release TFEB from its cytoplasmic anchor. Whether TFEB is retained in the nucleus will be dependent on the phosphorylation status of S138 and S142. Absence of phosphorylation of S138 or S142 will lead to nuclear retention. Note however that in this model dephosphorylation of S142 or S138 is not a necessary pre-requisite for nuclear entry