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. 2018 Jul 11;8:10446. doi: 10.1038/s41598-018-28842-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HDPs are active against planktonic bacteria. After 30 min of biofilm formation in the presence or absence of peptides, 5 μl of the medium was diluted and spread on TSA plates to determine viability of planktonic bacteria. (A) cCATH-1, 2 and 3, and (B) LL-37, CRAMP and IDR1018. Shown are averages of at least 3 independent experiments ± s.e.m. *Indicates statistical significance compared to the non-peptide control.