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. 2018 Jul 11;8:10426. doi: 10.1038/s41598-018-28745-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of rLOX-PP in in vivo angiogenesis CAM assay: (a) Representative photographs showing the rLOX-PP (2.5 μg/ mL) treated CAM, vehicle ctrl treated CAM and 10 ng/ml of VEGF treated CAM (positive control) at 0 h, 2 h and 4 h. (b) Quantification of the blood vessels in terms of measuring tubule length and (c) tubule junction. Vessel length and junction were noted (indicated in arrow) in each CAM and changes are shown in percentage in relation to the vehicle ctrl. Values are expressed as mean ± SD, n = 3. **p < 0.01 and *p < 0.05 versus Vehicle ctrl. *p < 0.05 versus 10 ng/mL of VEGF. (Vehicle ctrl – Vehicle control).