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. 2018 Jul 11;8:10426. doi: 10.1038/s41598-018-28745-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteomic analysis of LOX-PP overexpression in HUVECs: (a) Reactome and KEGG pathway analysis of the 372 uniquely expressed proteins in empty vector by ConsensusPathDB online tool (http://cpdb.molgen.mpg.de/) with p < 0.01, which showed components of VEGF signaling, MAPK signaling, RAF signaling and FGF signaling to be significantly increased. (b) Reactome and KEGG pathway analysis of the 75 uniquely expressed proteins in LOX-PP overexpressed cells by ConsensusPathDB online tool (http://cpdb.molgen.mpg.de/) with p < 0.01, which showed components of apoptosis, cell cycle and G2M check points to be increased. (c) Reactome and KEGG pathway analysis of proteins that are downregulated by LOX-PP overexpression. (d) Reactome and KEGG pathway analysis of proteins that are upregulated by LOX-PP overexpression.