Table 1.

The key residues, forming different important regions of AcrB involved in interaction with ligands or functional dynamics of the pump.

Region	K. pneumoniae AcrB Lining residues
Proximal binding site	S79, T91, S134, S135, K292, L572, M574, Q576, F616, T623, M661, F663, F665, N666, L667, L673, T675, D680, R716, N718, E825
Distal binding site	S46, Q89, S128, E130, S134, F136, Q176, L177, F178, S180, E273, N274, D276, I277, G290, Y327, L572, F609, V611, F614, F616, R619, F627
Cleft	F663, F665, L667, R716, L827
G-loop/Phe-loop	G615, F616, A617, G618
G-loop tip	Phe616
Postulate gate	Q124, Y757

Numbering is according to the amino acids’ positions in the K. pneumonia.