Skip to main content
. 2018 Jul 5;9:1551. doi: 10.3389/fimmu.2018.01551

Figure 1.

Figure 1

Development of IgG autoantibodies against double-stranded DNA (anti-dsDNA) antibodies in Dnase1l3-deficient mice. Sera from mice at the age of (A) 12–16 weeks, (B) 18–26 weeks, (C) 26–38 weeks, and (D) 40–52 weeks were tested for IgG anti-dsDNA antibodies by ELISA. The mice are grouped according to the genotype of the Dnase1l3tm1a mutation. All cohorts of mice are derived from 129 × C57BL/6 mixed background except homozygous mutant mice in (B) which are backcrossed to pure C57BL/6 background (B6−/−). Relative binding units are presented as compared to a standard serum pool from 9-month-old NZB/W mice. The dotted lines represent a cutoff derived from a panel of sera from C57BL/6 mice. Data are presented as box plot with individual data represented by filled circles (*p < 0.05; **p < 0.01; ***p < 0.001 Mann–Whitney U test).