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. 2018 Jul 5;10:203. doi: 10.3389/fnagi.2018.00203

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Copyright © 2018 Arroba, Campos-Caro, Aguilar-Diosdado and Valverde.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of changes in microglia during retinal neurodegeneration and the role of IGF-1 in this process. IGF-1 levels decrease along aging and in some neurodegenerative diseases and this is associated to a switch in microglia polarization toward a proinflammatory status. In this context, exosomes participate into cell-to-cell communications as vehicles which transport anti- or proinflammatory miRNAS.