Table 2.
Summary of Comparative Outcomes for Measurements of CSF Marker Levels.
| Cytokine | No. of studies | No. with PD/controls | Main effect | Heterogeneity | Publication bias | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hedges g (95% CI) | z score | p value | Q statistic | df | p value | I2 statistic | Egger intercept | p value | |||
| 8-OHdG | 3 | 86/71 | 0.816 (−0.120 to 1.751) | 1.708 | 0.088 | 15.561 | 2 | < 0.001 | 87.147 | 12.25750 | 0.31541 |
| Mn | 4 | 94/87 | 0.135 (−0.398 to 0.667) | 0.496 | 0.620 | 8.938 | 3 | 0.03 | 66.437 | −2.59509 | 0.66922 |
| Zn | 3 | 86/65 | 0.066 (−1.156 to 1.289) | 0.106 | 0.915 | 24.043 | 2 | < 0.001 | 91.681 | 10.74893 | 0.44572 |
| Cu | 4 | 117/100 | 0.325 (−0.332 to 0.982) | 0.969 | 0.333 | 15.733 | 3 | 0.001 | 80.932 | 7.02799 | 0.22078 |
| Fe | 6 | 361/175 | −0.131 (−0.606 to 0.344) | −0.540 | 0.589 | 35.582 | 6 | < 0.001 | 83.138 | −2.95205 | 0.54934 |
df, degrees of freedom; PD, Parkinson's Disease; CSF, cerebrospinal fluid; 8-OHdG, 8-hydroxyguanosine.