Table 2.

Summary of opioidergic drugs used as pharmacological intervention to counteract parkinsonian symptoms and dyskinetic movements in PD animal model.

Opioidergic drugs	Opioid receptor targets	Function	Effect
Cyprodine ADL5510	MOR	Antagonist	↓ LID (86, 87)
Naltrindole	DOR	Antagonist	↓ LID (86, 88) Akinesia (89)
SNC-80	DOR	Agonist	↑ Kinesia in PD state (90–92)
nor-BNI	KOR	Antagonist	No effect on LID (86)
U50,488	KOR	Agonist	↓ LID (93) ↑ Akinesia
Nalbuphine	KOR-MOR	Agonist-antagonist	↓ LID (94)
Naloxone	KOR-MOR-DOR	Antagonist	↓ LID (95, 96)

nor-BNI, nor-binaltorphimine; LID, levodopa-induced dyskinesia; PD, Parkinson disease.