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. 2018 Jul 5;9:824. doi: 10.3389/fphys.2018.00824

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Copyright © 2018 Martino, Perestrelo, Vinarský, Pagliari and Forte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC complex at the center of nuclear-cytoskeletal coupling. On the cytoplasmic side, different nesprin isoforms connect the nucleus to the cytoskeleton. Nesprin-1/2 directly bind actin, nesprin-3 is connected to intermediate filaments (IFs) by plectin and nesprin-4 binds microtubules (MTs) through kinesin-1 or other microtubule motor proteins. In the perinuclear space (PS), nesprins bind SUN proteins which span the inner nuclear membrane (INM) and interact with the nuclear lamina through lamin A. The inner nuclear membrane protein emerin anchors SUN protein to lamin A and interacts directly with chromatin. NPC, nuclear pore complex.