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. 2018 Jul 5;12:182. doi: 10.3389/fncel.2018.00182

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Copyright © 2018 Cui, Perez and Venance.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neocortical eCB-tLTP relies on transient receptor potential vanilloid type-1 (TRPV1) activation. (A) 10 pairings-tLTP was prevented when TRPV1 was inhibited by capsazepine, a specific TRPV1 inhibitor. Summary of experiments showing that tLTP expression was prevented by capsazepine (n = 8 cells from 4 rats; Δt_STDP = +17 ± 2 ms). (B) 10 pairings-tLTP was prevented when TRPV1 was inhibited by AMG9810, a specific TRPV1 inhibitor. Summary of experiments showing that AMG9810 prevented the 10 pairings tLTP (n = 7 cells from 3 rats; Δt_STDP = +16 ± 1 ms). Representative traces are the average of 15 EPSCs during baseline (black traces) and 50 min after STDP protocol (gray traces). Error bars represent SD. *p < 0.05. ns, non significant.