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. 2018 Jun 21;14:81–91. doi: 10.1016/j.jare.2018.06.004

Fig. 2.

Fig. 2

In vitro of toxicity of butenafine (5bd), its analogue (4bd) and corresponding hydrochloride salts (4bd.HCl and 5bd.HCl). Hemolytic activity of butenafine (5bd), its analogue (4bd) and corresponding hydrochloride salts (4bd.HCl and 5bd.HCl) (0.0625–32.0 µg/mL) and of Triton X-100 (0.0019–1% – positive control) on human erythrocytes (A and B; respectively). Cytotoxicity of butenafine (5bd), its analogue (4bd) and corresponding hydrochloride salts (4bd.HCl and 5bd.HCl) to HepG2. The survival rates of HepG2 cells were measured after treatment with serially diluted concentrations (0.125–8.0 µg/mL) of butenafine compounds (C). Cell viability was measured spectrophotometrically by detecting degradation of WST-1 dye into formazan by viable cells, which produces an intense color.