Table 2.
Minimal inhibitory concentration (MIC)a values (in µg/mL) of butenafine and its analogues against Cryptococcus neoformans, Cryptococcus gattii, Trichophyton rubrum and Microsporum gypseum.
| Compound | MIC values (µg/mL) |
|||
|---|---|---|---|---|
| M. gypseumb | T. rubrumc | C. neoformansd | C. gattiie | |
| 3ac | >64 | >64 | >64 | >64 |
| 4ac | >64 | >64 | >64 | >64 |
| 4ac.HCl | >64 | >64 | >64 | >64 |
| 5ac | >64 | >64 | >64 | >64 |
| 5ac.HCl | >64 | >64 | >64 | >64 |
| 3bc | >64 | >64 | >64 | >64 |
| 4bc | >64 | >64 | 64 | 64 |
| 4bc.HCl | 64 | 32 | 64 | 32 |
| 5bc | 32 | 4 | 64 | >64 |
| 5bc.HCl | 16 | 0.5 | 32 | 32 |
| 3ad | >64 | >64 | >64 | >64 |
| 4ad | >64 | >64 | >64 | >64 |
| 4ad.HCl | >64 | >64 | >64 | >64 |
| 5ad | >64 | >64 | >64 | >64 |
| 5ad.HCl | >64 | >64 | >64 | >64 |
| 3bd | >64 | >64 | >64 | >64 |
| 4bd | 2 | 0.5 | 16 | 8 |
| 4bd.HCl | 2 | 1 | 16 | 8 |
| 5bd | <0.125 | <0.125 | 1 | 1 |
| 5bd.HCl | <0.125 | <0.125 | 0.5 | 1 |
| 3ae | >64 | >64 | >64 | >64 |
| 4ae | >64 | >64 | >64 | >64 |
| 4ae.HCl | >64 | 32 | >64 | >64 |
| 5ae | >64 | >64 | >64 | >64 |
| 5ae.HCl | >64 | >64 | >64 | >64 |
| 3be | >64 | >64 | >64 | >64 |
| 4be | 4 | 8 | 8 | 4 |
| 4be.HCl | 8 | 4 | 8 | 4 |
| 5be | 0.5 | 0.25 | 16 | 32 |
| 5be.HCl | >64 | >64 | 16 | 32 |
a
MIC was visually determined as the concentration giving 100% inhibition of fungal growth compared with the control growth (non-treated fungi).
b
Clinical isolate.
c
ATCC number 40051.
d
ATCC number 28957.
e
ATCC number 32608.