Table 2.
Post-mortem μCT of Tibiae
| Sample Size | Intact |
E2 TG |
siCtrl TG |
siRANKL TG |
E2 PG |
siCtrl PG |
siRANKL PG |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| 2D Analysis of Tibiae | ||||||||||||||
| Number of N.Nd | 28.9*,** | 8.6 | 7.8*** | 3.3 | 8.6*** | 3.1 | 8.9*** | 4.3 | 29.2*,**,**** | 9.2 | 9.6*** | 7.1 | 8.5*** | 5.1 |
| % Trabecular density | 43.8*,** | 13.1 | 13.6*** | 3.3 | 11.3*** | 2.5 | 13.4*** | 3.9 | 33.3*,**,***,**** | 3.3 | 13.9*** | 5.9 | 11.6*** | 3.7 |
| Tb Wi (μm) | 176.7*,** | 63.7 | 67.8*** | 7.5 | 67.8*** | 8.2 | 73.1*** | 9.5 | 111.3*,**,***,**** | 25.1 | 67.4*** | 10.4 | 66.6*** | 9.1 |
| Trabecular bone area (mm2) | 4.4*,** | 1.4 | 1.3*** | 0.2 | 1.3*** | 0.3 | 1.4*** | 0.4 | 3.6*,**,***,**** | 0.7 | 1.5*** | 0.6 | 1.3*** | 0.5 |
| Ct Wi (μm) | 477.7 | 76.4 | 444.1 | 48.9 | 476.8 | 67.3 | 460.6 | 54.9 | 478.9 | 75.5 | 464.6 | 69.8 | 465.1 | 65.7 |
| 3D Analysis Tibiae | ||||||||||||||
| BMD [mg/cm3] | 649.5 | 142.5 | 486.9 | 94.5 | 542.4 | 88.4 | 498.6 | 112.2 | 641.6**** | 53.9 | 504.2 | 109.5 | 500.5 | 69.9 |
| % BV/TV [%] | 53.8** | 9.1 | 39.4*** | 6.8 | 44.4 | 6.2 | 40.5*** | 7.5 | 50.7*,**,**** | 4.4 | 40.4*** | 7.2 | 40.3*** | 3.8 |
| Trabecular number (Tb. N) | 187.9*,** | 60.9 | 32.6*** | 16.8 | 20.4*** | 30.2 | 26.9*** | 12.9 | 104.1*,**,***,**** | 45.8 | 39.6*** | 22.3 | 19.5*** | 8.5 |
| Trabecular volume (mm3) | 3.14*,** | 1.53 | 0.54*** | 0.24 | 0.47*** | 0.49 | 0.51*** | 0.22 | 1.83**,***,**** | 0.85 | 0.81*** | 0.38 | 0.29*** | 0.13 |
| Number of N.Nd | 223.7*,** | 72.5 | 33.6*** | 12.8 | 19.9*** | 29.9 | 22.1*** | 12.6 | 113.6*,**,***,**** | 54.5 | 39.9*** | 24.5 | 18.5*** | 9.8 |
For all groups, n = 8. *p < 0.05 versus Ctrl; **p < 0.05 versus siRANKL; ***p < 0.05 versus intact; ****p < 0.05 versus TG.