Sensing scheme for the SPR signal amplification with liposomes. Liposomes are used as label subsequent to the analyte binding to the SPR surface. Although this renders the traditionally label-free SPR method to a label-based detection system, this approach will enable the detection of bound analytes present at low concentration and those providing only minimal changes in RI. Reprinted from Fenzl, C.; Hirsch, T.; Baeumner, A. J. Anal. Chem. 2015, 87, 11157–11163 (ref 180). Copyright American Chemical Society 2015.