Figure 3.

Tumor size and weights in xenograft model involving sunitinib (30 mg/kg) and evofosfamide (50 mg/kg).

The image on the left (A) shows the comparison of tumor sizes after treatment with sunitinib (SU) and evofosfamide (Evo) in xenograft model where treatment with sunitinib was started 7 days prior to evofosfamide treatment (CT-1). Comparison of tumor weights is shown below the image. All three treatment groups (SU, Evo, and SU+Evo) had significantly lower tumor weights compared to that of control group (P=.0005, .003, and .0005 for SU, Evo, and SU+Evo, respectively). Both SU (P=.009) and SU+Evo (P=.007) groups had significantly lower tumor weights than Evo group. The image on the right (B) shows the comparison of tumor sizes in experiment where treatments with sunitinib and evofosfamide were started simultaneously (CT-2). All three treatment groups had significantly lower tumor weights compared to control (P<.0001). In both the graphs, asterisks above the bar represent P values compared to the control, whereas those depicted along with lines represent P values between combination and respective single-agent–treated groups.