Table 2.
List of In Vivo Experiments Conducted to Test the Efficacies of Sunitinib and Evofosfamide
| Regimen | Model | Figure | Time of Start | End | Dose (mg/kg) |
|
|---|---|---|---|---|---|---|
| Sunitinib | Evofosfamide | |||||
| Evofosfamide | Metastatic | 2 | 45 days post IV injection of tumor cells | 15 days of treatment | - | 50 |
| Combination (CT-1) | Xenograft | 3A | Sunitinib started when average tumor size reached 0.5 cm diameter; evofosfamide started 1 week after sunitinib | 4 weeks from the start of sunitinib | 30 | 50 |
| Combination (CT-2) | Xenograft | 3B | Both drugs started when average tumor size reached 0.5 cm diameter | 4 weeks | 30 | 50 |
| Combination (CT-3) | Xenograft | 4A | 20 days after the implantation of tumor cells | Till end point | 80 | 50 |
| Combination (CT-4) | IV metastatic | 4 B | 20 days post IV injection of cells | 12 days of treatment | 80 | 50 |