Table 6.
Significant association of MIR137 rs1625579 polymorphism with symptom expression degree according to PANSS in schizophrenia patients.
| Subscales | Mean symptom expression degree, points | P-level, α = 0.05 | ||
|---|---|---|---|---|
| T/T (91 subjects) | T/G (49 subjects) | G/G (10 subjects) | ||
| TOTAL INDEX OF POSITIVE SYMPTOMS | ||||
| PANSS_P | TT | TG | GG | |
| 21.02 ±5.6 | 18.76 ± 4.52 | 20.00 ±7.42 | 0.043 | |
| TG+GG | TT | |||
| 18.97 ±5.07 | 21.02 ±5.6 | 0.015 | ||
| TT+GG | TG | |||
| 20.92 ±5.77 | 18.76 ±4.52 | 0.016 | ||
| TOTAL INDEX OF GENERAL PSYCHOPATHOLOGICAL SYMPTOMATOLOGY | ||||
| PANSS_G | TT | TG | GG | |
| 36.30 ± 7.24 | 33.14 ± 7.17 | 38.20 ± 10.14 | 0.057 | |
| TT+GG | TG | |||
| 36.49 ± 7.54 | 33.14 ± 7.17 | 0.019 | ||
| TOTAL INDEX OF ALL PANSS SYMPTOMS | ||||
| PANSS_Total | TT | TG | GG | |
| 84.53 ± 13.99 | 77.31 ± 14.46 | 87.20 ± 20.05 | 0.018 | |
| TG+GG | TT | |||
| 78.98 ± 15.79 | 84.53 ± 13.99 | 0.016 | ||
| TT+GG | TG | |||
| 84.79 ± 14.59 | 77.31 ± 14.46 | 0.005 | ||
PANSS_P, variable reflecting positive symptom complex of PANSS; PANSS_N, variable reflecting all symptoms of general psychopathological subscale of PANSS (reflects schizophrenic disorder severity in general); PANSS_Total, variable reflecting all PANSS symptoms. Values are represented as Mean ± SD. Bold values indicate the mean statistical significance or % value.