Table 3.
Grade | HER2 | Nodes | Ki67 | ER | |
---|---|---|---|---|---|
(a) Binary predictor | |||||
2-sample | 0.57 | 0.61 | 0.59 | 0.55 | 0.53 |
Harrell | 0.59 | 0.57 | 0.63 | 0.61 | 0.56 |
Uno | 0.58 | 0.57 | 0.63 | 0.58 | 0.56 |
PH | 0.57 | 0.54 | 0.60 | 0.59 | 0.56 |
Pareto | 0.53 | * | * | 0.53* | |
PH (LR-χ2) | 0.9 (24.9) | 1.1 (23.1) | 1.2 (47.5) | 0.8 (21.6) | −0.5 (7.8) |
Pareto (LR-χ2) | 1.3 (27.0) | * | * | 1.4 (25.2)* | |
(LR-χ2) | 4.0 (2.1) | 0.0 (0.0) | 0.0 (0.0) | 8.7 (3.6) | 0.0 (0.0) |
(b) Continuous predictor | |||||
Harrell | 0.65 | 0.64 | 0.57 | ||
Uno | 0.64 | 0.62 | 0.58 | ||
PH | 0.61 | 0.63 | 0.57 | ||
Pareto | * | 0.55 | 0.54 | ||
PH (LR-χ2) | 1.0 (72.7) | 0.4 (31.8) | −0.2 (11.5) | ||
Pareto (LR-χ2) | * | 0.7 (35.2) | −0.2 (12.0) | ||
(LR-χ2) | 0.0 (0.0) | 6.6 (3.5) | 2.8 (0.4) |
PH: using proportional-hazards assumption and (10); Grade: moderate or worse; HER2: positive; Nodes: lymph node positive or number of nodes (ordinal: 0, 1–3, > 4); Ki67: above median or continuous marker; ER: oestrogen-receptor score above median or continuous; LR-χ2: likelihood-ratio statistic; : estimated regression coefficient for predictor; * indicates when Pareto model fit was proportional hazards.