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. 2016 Dec 29;27(8):2359–2373. doi: 10.1177/0962280216680245

Table 3.

Estimated univariate concordance indices and model coefficients from example.

Grade HER2 Nodes Ki67 ER
(a) Binary predictor
 2-sample 0.57 0.61 0.59 0.55 0.53
 Harrell 0.59 0.57 0.63 0.61 0.56
 Uno 0.58 0.57 0.63 0.58 0.56
 PH 0.57 0.54 0.60 0.59 0.56
 Pareto 0.53 * * 0.53*
 PH β^(LR-χ2) 0.9 (24.9) 1.1 (23.1) 1.2 (47.5) 0.8 (21.6) −0.5 (7.8)
 Pareto β^(LR-χ2) 1.3 (27.0) * * 1.4 (25.2)*
γ^(LR-χ2) 4.0 (2.1) 0.0 (0.0) 0.0 (0.0) 8.7 (3.6) 0.0 (0.0)
(b) Continuous predictor
 Harrell 0.65 0.64 0.57
 Uno 0.64 0.62 0.58
 PH 0.61 0.63 0.57
 Pareto * 0.55 0.54
 PH β^(LR-χ2) 1.0 (72.7) 0.4 (31.8) −0.2 (11.5)
 Pareto β^(LR-χ2) * 0.7 (35.2) −0.2 (12.0)
γ^(LR-χ2) 0.0 (0.0) 6.6 (3.5) 2.8 (0.4)

PH: using proportional-hazards assumption and (10); Grade: moderate or worse; HER2: positive; Nodes: lymph node positive or number of nodes (ordinal: 0, 1–3, > 4); Ki67: above median or continuous marker; ER: oestrogen-receptor score above median or continuous; LR-χ2: likelihood-ratio statistic; β^: estimated regression coefficient for predictor; * indicates when Pareto model fit was proportional hazards.