Table 2.
Change From Baseline in Measures of Cardiac Dimensions and Cardiac Function by Treatment Arm
| ActRIIB.Fc | Control | Difference | P Value | |
|---|---|---|---|---|
| Somatometrics | ||||
| Body weight, kg | 0.526 ± 0.112 | 0.049 ± 0.104 | 0.477 ± 0.156 | 0.012 |
| Body surface area, cm2 | 186.2 ± 46.8 | 52.1 ± 43.1 | 134.1 ± 65.9 | 0.069 |
| Cardiac dimensions | ||||
| LV internal diameter at diastole, cm | 0.013 ± 0.053 | 0.058 ± 0.049 | −0.045 ± 0.073 | 0.555 |
| LV Internal diameter at systole, cm | −0.105 ± 0.044 | −0.037 ± 0.041 | −0.068 ± 0.061 | 0.290 |
| Interventricular septum thickness at diastole, cm | 0.113 ± 0.024 | 0.008 ± 0.023 | 0.105 ± 0.033 | 0.010 |
| Interventricular septum thickness at systole, cm | 0.105 ± 0.037 | −0.020 ± 0.034 | 0.124 ± 0.051 | 0.036 |
| LV posterior wall at diastole, cm | 0.109 ± 0.022 | −0.013 ± 0.020 | 0.122 ± 0.030 | 0.002 |
| LV posterior wall at systole, cm | 0.169 ± 0.046 | 0.022 ± 0.043 | 0.146 ± 0.063 | 0.044 |
| Left atrium diameter, cm | 0.173 ± 0.058 | 0.044 ± 0.053 | 0.129 ± 0.079 | 0.133 |
| Aortic root diameter, cm | 0.032 ± 0.027 | 0.005 ± 0.025 | 0.027 ± 0.037 | 0.489 |
| Left atrium:aorta ratio | 0.137 ± 0.058 | 0.043 ± 0.054 | 0.094 ± 0.080 | 0.268 |
| Cardiac function | ||||
| Heart rate, beats/min | 28.2 ± 8.7 | −7.1 ± 8.0 | 35.3 ± 12.0 | 0.015 |
| End-diastolic volume, mL | −1.17 ± 1.05 | 0.97 ± 0.97 | −2.14 ± 1.46 | 0.174 |
| End-diastolic volume index, mL/m2 | −0.0007 ± 0.0004 | 0.0003 ± 0.0004 | −0.001 ± 0.0006 | 0.078 |
| Stroke volume, mL | 1.07 ± 0.67 | 0.79 ± 0.62 | 0.28 ± 0.93 | 0.770 |
| End-systolic volume, mL | −0.689 ± 0.238 | −0.148 ± 0.220 | −0.542 ± 0.328 | 0.129 |
| End-systolic volume index, mL/m2 | −0.0003 ± 0.0001 | −0.00006 ± 0.00009 | −0.0003 ± 0.0001 | 0.054 |
| Fractional shortening, % | 6.54 ± 1.88 | 4.20 ± 1.74 | 2.34 ± 2.56 | 0.381 |
| Ejection fraction, % | 7.47 ± 2.36 | 2.49 ± 2.18 | 4.98 ± 3.22 | 0.153 |
| Cardiac output, mL/min | 390.7 ± 133.8 | 82.1 ± 123.6 | 308.6 ± 184.2 | 0.125 |
| Cardiac index, mL/min/m2 | 0.106 ± 0.049 | 0.037 ± 0.046 | 0.069 ± 0.067 | 0.328 |
Estimated means and 95% CIs by treatment arm and for the difference between groups. Effects expressed as change from baseline and derived from the analysis of covariance model. P value for difference between groups in changes from baseline.
Abbreviations: CI, confidence interval; LV, left ventricular.