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. 2018 Jun 13;2(8):842–854. doi: 10.1210/js.2018-00077

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Figure 1. — Structural analysis of VUSs occurring in LDLR and CASR. (Left) p.Cys284Ser abolishes a cysteine bond in the LDLR protein. (Middle) p.Gly143Arg may disrupt Ca⁺ (presented as a sphere) binding site in CASR protein. (Right) p.Cys568Gly is likely to disrupt a disulfide bridge in the CASR protein.