Table 1.

Effect of Antioxidants on Host Antitumor Immunity: Evidences From Preclinical Studies.

Treatment	Experimental Model	Results	References
Curcumin	Swiss albino mice with Ehrlich ascites carcinoma cells	Restoration of tumor-induced depletion of host CD4+/CD8+ T cell proliferation, inhibition of thymocytes and splenocytes apoptosis, expansion of central memory and effector memory T cells and inhibition of suppressive activity of Tregs	27, 28
Resveratrol	BALB/c mice with 4T1 breast carcinoma cells	Inactivation of Stat3, prevention of tumor-evoked regulatory B cells (tBregs) generation and function and restricting the tBreg-induced conversion of FoxP3+ Tregs	34
Resveratrol	C57BL/6 and BABL/c mice with EG6 lymphoma and CT26 colon carcinoma cell lines	Suppression of tumor-derived Tregs	35
Fish oil and selenium yeast	BALB/cByJ mice with Line-1 and YAC-1 lymphoma cells	Decreased populations of immunosuppressive Tregs and myeloid-derived suppressor cells	36