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. 2018 Aug;94(2):926–937. doi: 10.1124/mol.118.112359

Fig. 1.

Fig. 1.

VU0134992 exhibits preference for Kir4.1 over Kir4.1-5.1 channels. (A) Chemical structure of VU0134992. (B) Representative traces showing inhibition of Kir4.1 homomeric and Kir4.1-5.1 heteromeric currents recorded in the absence (blue) or presence (red) of 3 µM VU0134992 and 2 mM BaCl2 (black). (C) Mean ± S.D. CRCs of VU0134992 for homotetrameric Kir4.1 and heterotetrameric concatemer of Kir4.1/5.1 currents measured at −120 mV (n ≥ 5). (D) Mean ± S.D. CRCs of VU0134992 for homotetrameric Kir4.1 and heterotetrameric concatemer of Kir4.1/5.1 currents measured at +120 mV (n ≥ 5).