Fig. 2.

VU0134992 exhibits voltage-dependent block of Kir4.1 (A) Representative whole-cell current responses to voltage steps (1 second) from a holding potential (−80 mV for 5 mM K⁺ or −25 mV for 50 mM K⁺) in the presence or absence of 30 µM VU0134992. (B) Percentage of VU0134992 inhibition was calculated at each voltage with 5 and 50 mM extracellular K⁺. The VU0134992-induced block of Kir4.1 was statistically significantly lower at −120 and −100 mV in 50 mM K⁺ compared with 5 mM K⁺ containing bath solution. *P < 0.05, statistically significantly different from the 5 mM K⁺ extracellular solution control (n ≥ 5).