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. 2018 Jul 12;14(3):149–158.

Figure 2.

Figure 2

The transcription levels of genes related to the Insig-SREBP pathway. Data show the signal log ratio to their respective control. (a) The transcription level of genes regulated by SREBP-1c. (b) The transcription level of genes regulated by SREBP-2. (c) The transcription levels of NADPH-related genes regulated by both SREBP-1c and SREBP-2. (a–c) The transcription levels of the downstream enzyme genes of the SREBP pathway were mostly inhibited by 1 week of Ath diet, then induced by the 10-week Ath diet, and finally restored by atorvastatin treatment. (d) The transcription level of SREBP-1 was induced by 1 week and 10 weeks of Ath diet and slightly reversed by atorvastatin treatment, while that of Insig-2 was reduced by 1 week and 10 weeks of Ath diet but partially restored by atorvastatin treatment. The transcription level of SCAP remained stable. Lss and SREBP2 were omitted because their cell calls were ‘absent” in all five groups. *: robust increase in Ath10w; #: robust decrease in Ath10w; †: robust increase in ST; Δ: robust decrease in ST; ^: robust decrease in Ath1w. Acas: acetyl-CoA synthetase; Acyl: ATP citrate lysase; Acacb: acetyl-CoA carboxylase beta; Fasn: fatty acid synthase; Elovl: elongation of very long chain fatty acids; Scd: stearoyl-CoA desaturase; Gpam: glycerol-3-phosphate acyltransferase, mitochondrial; Mvd: mevalonate (diphospho) decarboxylase; Hmgcr: 3-hydroxy-3-methylgltaryl-CoA reductase; Hmgcs: 3-hydroxy-3-methylgltaryl-CoA synthase; Dhcr7: 7-dehydrocholesterol reductase; Cyp51: cytochrome P450, 51; Idi1: isopentenyl-diphosphate delta isomerase; Aacs: acetoacetyl-CoA synthetase; Pmvk: phosphomevalonate kinase; Fdps: farnesyl diphosphate synthase; Ggps: geranylgeranyl diphosphate synthase; Sqle: squalene epoxidase; Lss: lanosterol synthase; Sc5d: sterol-C5-desaturase; Ldlr: low-density-lipoprotein cholesterol receptor; Mod: malic enzyme; G6pd2: glucose-6-phosphate dehydrogenase 2; Pgd: phosphogluconate dehydrogenase; Srebp: sterol regulatory element binding protein; Scap: Sreb cleavage-activating protein; Insig: insulin induced gene.