Table 1.

Examples of CRISPR/ Cascade 9-mediated genome editing in human cells and model organisms.

Different approaches	Organisms	Genes	References
Gene knockout	INVERTERBRATES
	Drosophila	Yellow, white, AGO1	Bassett et al., 2013, 2014
	Silkworm	BmWnt1, BmBLOS2 Bm-ok, BmKMO, BmTH, and Bmtan	Wang et al., 2013; Zhang et al., 2015 Wei et al., 2014
	Caenorhabditis elegans	csr-1, mes-6, dpy-3, unc-1	Cho et al., 2013b; Chen et al., 2015
	Yeast	ADE2	Giersch and Finnigan, 2017
	VERTEBRATES
	Human	H69, DMRT1, DMRT3, NF1, MED12, NF2, CUL3, TADA2B, TADA1, MAGEC2, S100A4, OCIAD1	Shalem et al., 2014; Shetty and Inamdar, 2016; Tahara et al., 2016; Wang et al., 2016; Inui et al., 2017; Wills et al., 2017
	Zebrafish	cyp19a1a, valopa, valopb	Hang et al., 2016; Lau et al., 2016
	Mouse	Rp9	Lv et al., 2017
	Chicken	Stra8, Myostatin	Lee et al., 2017; Zhang et al., 2017
	Monkey	Ppar-γ, Rag1	Niu et al., 2014
	PLANTS
	Arabidopsis Tobacco Sorghum and Rice	OsSWEET14 and OsSWEET11, PDS3, TTG1, IAA2, CDK	Jiang et al., 2013; Endo et al., 2015; Ryder et al., 2017; Tsutsui and Higashiyama, 2017
Gene knock-in	INVERTERBRATES
	Drosophila	nanos, yellow locus, white locus	Xue et al., 2014; Port et al., 2015
	Silkworm	Bmku70	Ma et al., 2015
	Caenorhabditis elegans	unc-119	Zhao et al., 2014
	VERTERBRATES
	Human	DACT1, IFIT1and EGR1	Zhang et al., 2006
	Zebrafish	zebrafish th, tardbp, fus	Armstrong et al., 2016
	Mouse	Rosa26, KRAS, p53,LKB1	Li et al., 2015
	Chicken	yRad52	Platt et al., 2014; Chu et al., 2016
	Pig	COL1A	Park et al., 2016; Wang et al., 2017a
	PLANTS
	Arabidopsis	PDS3, AtFLS2	Li et al., 2014
	Tobacco	No
	Rice	WDV	Wang et al., 2017
Gene Knockdown and silencing approaches	INVERTERBRATES
	Drosophila	roX1, roX2,	Ghosh et al., 2016
	Caenorhabditis elegans	TRHR-1
	Silkworm	No	Van Sinay et al., 2017
	VERTERBRATES
	Human Zebrafish Mouse Chicken Pig	EPHA1 mmp21 Nrl No No	Cui et al., 2017 Guimier et al., 2015 Yu et al., 2017
Gene correction	INVERTERBRATES
	Drosophila	No
	Caenorhabditis elegans	No
	Silkworm	No
	VERTERBRATES
	Human	MYBPC3	Ma et al., 2017
	Zebrafish	No
	Mouse	Hemophilia B, Pde6b
	Chicken	No	Huai et al., 2017
	Pig	No
Conditional approaches	INVERTERBRATES
	Drosophila	bam, nos, cid, ms(3)k81, wg	Port et al., 2014; Xue et al., 2014
	Caenorhabditis elegans	dpy-5, lon-2, unc-76
	Silkworm	No	Shen et al., 2014
	VERTERBRATES
	Human	puroR, Ctnnb1	Shen et al., 2014
	Zebrafish	tyr, insra; insrb, ascl1a
	Mouse	Mecp2, Ispd, Kras; p53; Lkb 1	Yin L. et al., 2015
	Chicken	No	Yang et al., 2013; Lee and Lloyd, 2014; Platt et al., 2014
	Pig	PFFs	Liu et al., 2016