TABLE 3.
SELECTED PATHWAYS WITH HIGHLY VARIABLE TRANSCRIPTS IN OM AND SC ADIPOSE TISSUE, BASED ON THE COEFFICIENT OF VARIATION IN GENE EXPRESSION LEVEL
| Omental Adipose Tissue | Subcutaneous Adipose Tissue | ||||
|---|---|---|---|---|---|
| Pathway | No. of Genes | Symbols | Pathway | No. of Genes | Symbols |
| Aminosugars metabolism | 2 | UAP1, GFPT2 | Aminosugars metabolism | 1 | HEXB |
| Antigen processing and presentation | 2 | HSPA1A, HSPA1B | Antigen processing and presentation | 4 | IFI30, CTSB**, CTSS, CTSL |
| Arachidonic acid metabolism | 1 | PLA2G2A | Arachidonic acid metabolism | 1 | PLA2G2A |
| Cell adhesion molecules (CAMs) | 1 | ICAM1* | Cell adhesion molecules (CAMs) | 2 | ITGB2, ALCAM |
| Cell communication | 1 | LMNA* | Cell communication | 3 | SPP1, COL1A2, THBS1 |
| Cell cycle | 1 | GADD45B | Cell cycle | 1 | CDC16 |
| Fc epsilon RI signaling pathway | 2 | PLA2G2A, MAP2K3 | Fc epsilon RI signaling pathway | 2 | PLA2G2A, FCER1G |
| Focal adhesion | 1 | JUN | Focal adhesion | 3 | SPP1, COL1A2, THBS1 |
| Glycan structures—biosynthesis 2 | 1 | UGCG | Glycan structures—degradation | 2 | GUSB,HEXB |
| Glycerophospholipid metabolism | 1 | PLA2G2A | Glycerophospholipid metabolism | 1 | PLA2G2A |
| GnRH signaling pathway | 2 | PLA2G2A, MAP2K3 | GnRH signaling pathway | 1 | PLA2G2A |
| Hematopoietic cell lineage | 1 | TFRC* | Hematopoietic cell lineage | 2 | TFRC, CD9 |
| Leukocyte transendothelial migration | 1 | ICAM1* | Leukocyte transendothelial migration | 3 | ITGB2, MMP9, TFRC |
| Linoleic acid metabolism | 1 | PLA2G2A | Linoleic acid metabolism | 1 | PLA2G2A |
| Long-term depression | 1 | PLA2G2A | Long-term depression | 1 | PLA2G2A |
| MAPK signaling pathway | 6 | GADD45B, HSPA1A, HS-PA1B, JUN, PLA2G2A, MAP2K3 | MAPK signaling pathway | 1 | PLA2G2A |
| mTOR signaling pathway | 1 | HIF1A | mTOR signaling pathway | 1 | TSC1 |
| Natural killer cell mediated cytotoxicity | 2 | ICAM1*, FCGR3B | Natural killer cell mediated cytotoxicity | 3 | ITGB2, FCER1G, TYROBP |
| Ribosome | 1 | RPS26 | Ribosome | 1 | RPS26 |
| Toll-like receptor signaling pathway | 4 | NFKBIA, MAP2K3, | Toll-like receptor signaling pathway | 1 | TBK1 |
| VEGF signaling pathway | 1 | PLA2G2A | VEGF signaling pathway | 1 | PLA2G2A |
| Wnt signaling pathway | 1 | JUN | Alkaloid biosynthesis II | 1 | LIPA |
| Adipocytokine signaling pathway | 1 | NFKBIA | Alzheimer’s disease | 1 | APOE* |
| Apoptosis | 1 | NFKBIA | ATP synthesis | 1 | ATP6V0B |
| B cell receptor signaling pathway | 2 | NFKBIA, JUN | Bile acid biosynthesis | 1 | LIPA |
| Cytokine–cytokine receptor interaction | 1 | CCL8 | Carbon fixation | 1 | PKM2 |
| Epithelial cell signaling in Helicobacter pylori infection | 1 | NFKBIA | Cholera—infection | 1 | ATP6V0B |
| Glutamate metabolism | 1 | GFPT2 | ECM-receptor interaction | 3 | SPP1, COL1A2, THBS1 |
| Glycosphingolipid metabolism | 1 | UGCG | Globoside metabolism | 1 | HEXB |
| Jak-STAT signaling pathway | 1 | PIM1 | Glutathione metabolism | 1 | GSTOl |
| Methionine metabolism | 1 | MAT2A | Glycerolipid metabolism | 1 | LIPA |
| Nicotinate and nicotinamide metabolism | 2 | NNMT, PBEF1 | Glycolysis/gluconeogenesis | 1 | PKM2 |
| Selenoamino acid metabolism | 1 | MAT2A | Glycosaminoglycan degradation | 2 | GUSB, HEXB |
| T cell receptor signaling pathway | 2 | NFKBIA, JUN | Insulin signaling pathway | 2 | PKM2, TSC1 |
| Metabolism of xenobiotics by cytochrome P450 | 1 | GSTOl | |||
| Neurodegenerative Disorders | 1 | APOE* | |||
| N-Glycan degradation | 1 | HEXB | |||
| Oxidative phosphorylation | 1 | ATP6V0B | |||
| Pentose and glucuronate interconversions | 1 | GUSB | |||
| Porphyrin and chlorophyll metabolism | 1 | GUSB | |||
| Pyruvate metabolism | 1 | PKM2* | |||
| Regulation of actin cytoskeleton | 2 | ITGB2, ARPC1B | |||
| SNARE interactions in vesicular transport | 1 | VAMP8 | |||
| Starch and sucrose metabolism | 1 | GUSB | |||
| TGF-beta signaling pathway | 1 | THBS1 | |||
| Thiamine metabolism | 1 | THTPA | |||
| Type II diabetes mellitus | 1 | PKM2 | |||
| Ubiquitin mediated proteolysis | 1 | CDC16 | |||
*
Two probesets generated similar results for these genes.