TABLE 4.
GENES ASSOCIATED WITH THE TOP FUNCTION IN THE OM AND SC DATASETS CONTAINING HIGHLY VARIABLE TRANSCRIPTS
| Category/Process | Genes |
|---|---|
| Omental adipose tissue: cell death | |
| Cell death | ATF3, CYR61, DNAJB1, EMP1, GADD45B, HIF1A, HSPA1A, HSPA1B, ICAM1, IER3, JUN, JUNB, KLF4, MAP2K3, MCL1, MT1X, MT2A, NFIL3, NFKBIA, PBEF1, PIM1, PRG1, S100A8, SGK, TBK1, TFRC, TNFAIP3, UGCG |
| Apoptosis | ATF3, CYR61, GADD45B, HIF1A, HSPA1A, HSPA1B, ICAM1, IER3, JUN, KLF4, MAP2K3, MCL1, MT2A, NFIL3, NFKBIA, PBEF1, PIM1, PRG1, S100A8, SGK, TBK1, TFRC, TNFAIP3, UGCG |
| Killing | HSPA1A, HSPA1B, S100A8 |
| Cell viability | LMNA, MCL1, MT2A, NFKBIA, TNFAIP3, UGCG |
| Cytotoxicity | FCGR3B, MT2A, TNFAIP3 |
| Survival | CYR61, HIF1A, HSPA1B, JUN, MCL1, NFIL3, NFKBIA, PIM1, UGCG |
| Colony survival | JUN |
| Inhibition | HSPA1B, IER3, MCL1 |
| Activation-induced cell death | ICAM1 |
| Subcutaneous adipose tissue: lipid metabolism | |
| Storage | ADFP, GM2A, LIPA, SCD |
| Quantity | APOC1, APOE, CTSS, FCER1G, LIPA, NR1H3, PLA2G2A, SCD, UCP2, IL1RN |
| Synthesis | APOE, CD9, FCER1G, NR1H3, PLA2G2A, SCD |
| Release | CTSB, FCER1G, IL1RN, PLA2G2A |
| Modification | APOE, PLA2G2A, SCD, UCP2, ITGB2 |
| Efflux | APOE, NR1H3, SAA1 |
| Hydrolysis | GM2A, HEXB, PLA2G2A |
| Accumulation | APOE, NR1H3, IL1RN, UCP2, APOC1 |
| Production | APOE, IL1RN, ITGB2, PLA2G2A, NR1H3 |
| Activation | NR1H3 |
| Esterification | APOE, SCD |
| Oxidation | APOE, SCD, UCP2 |
| Peroxidation | APOE, PLA2G2A |
| Co-capping | ITGB2 |
| Uptake | APOC1, APOE |
| Metabolism | APOC1, APOD, IL1RN, PLA2G2A, SCD |
| Exchange | APOC1 |
| Liberation | PLA2G2A |
| Degradation | GM2A, PLA2G2A |
| Desaturation | SCD |
| Secretion | APOE, SCD |
| Steroidogenesis | APOE |
| Transport | ADFP |