Table 1.
Level of Consensus on Definition of Treatment Failure in Knee Osteoarthritis.
| Issues on Definition of Treatment Failure in Knee OA | Level of Consensus | Agreement |
|
|---|---|---|---|
| Agree | Disagree | ||
| Do you agree or disagree with the following definition of “treatment failure six months after VS”? | |||
| Pain decrease on VAS <20 mm | Moderately in favor | 7 | 3 |
| Pain decrease on VAS or WOMAC score <50% | Strongly against | 2 | 8 |
| Pain decrease on VAS or WOMAC score <MCII | Strongly in favor | 8 | 2 |
| Remaining pain >PASS | Strongly in favor | 9 | 1 |
| Pain decrease <MCII and pain >PASS | Moderately in favor | 7 | 3 |
| Pain decrease >MCII and pain <PASS but patient dissatisfied | Strongly in favor | 8 | 2 |
| Pain decrease <MCII and pain >PASS but patient satisfied | Strongly against | 2 | 8 |
| To demonstrate the “treatment failure,” what are the most useful tools, in daily practice | |||
| WOMAC pain score variation | No consensus | 5 | 5 |
| KOOS variation | Strongly against | 2 | 8 |
| MCII | Weakly in favor | 6 | 4 |
| PASS | Strongly in favor | 8 | 2 |
| OMERACT-OARSI response criteria | Moderately against | 3 | 7 |
| Patient’s overall opinion | Unanimously in favor | 10 | 0 |
| To demonstrate the “treatment failure,” what are the most useful tools, in clinical trials | |||
| WOMAC pain score variation | Strongly in favor | 9 | 1 |
| KOOS variation | Moderately in favor | 7 | 3 |
| MCII | Strongly in favor | 8 | 2 |
| PASS | Strongly in favor | 8 | 2 |
| OMERACT-OARSI response criteria | Moderately in favor | 7 | 3 |
| Patient’s overall opinion | Strongly in favor | 9 | 1 |
OA = osteoarthritis; VAS = 100 mm visual analogue scale; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index; PASS = Patient’s Acceptable Symptom State; MCII = Minimal Clinically Important Improvement; KOOS = Knee injury and Osteoarthritis Outcome Score; OMERACT-OARSI = Outcome Measures in Clinical Trials–Osteoarthritis Research Society International.