Fig. 3.

Deletion of astrocytic Cx43 improves neuroretinal function in OIR. (A) Recordings of (Left) a and b waves and (Right) OPs of scotopic ERGs in response to different stimulus intensities from Cx43^flox and Cx43^aKO mice exposed to OIR. Light intensities in log scot. cd s/m² are shown to the left of each trace. (B and C) Cx43^aKO mice showed a significant improvement in function of the neural retina. (B) Quantification of the amplitudes of the scotopic b wave and (C) summed OPs at different stimulus intensities. Lines in B represent the fit of the Naka Rushton equation to the data. Data are presented as mean ± SEM (n = 5 each of Cx43^flox and Cx43^aKO mice). Student’s t test, *P < 0.05.