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Compound 1 interacts with the LPS flippase MsbA. (A) Mutations (shown in orange and magenta in the two respective monomers) identified in MsbA map to its transmembrane region (structure from S. typhimurium; PDB ID code 3B60). The most prevalent mutation, L150V, is colored blue. (B) Compound 1 stimulates ATPase activity (n = 2; error bars = SE) of WT MsbA in vitro. The L150V mutation attenuates this effect. In contrast, the inactive compound 2 does not affect ATPase activity.
