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. 2018 Jun 11;115(26):6816–6821. doi: 10.1073/pnas.1804262115

Fig. 3.

Fig. 3.

Click chemistry enables the facile synthesis of thermoresponsive, antioxidant peptide-PPCN. (A) Schematic illustrating A5G81-PPCN self-assembly due to temperature change (Left). A5G81 peptide conjugation to PPCN via the cross-linker BMPH (Right). The same amount of peptide was conjugated across different peptide groups. (B) MALDI-TOF spectrum of A5G81-PPCN confirming the presence of the PPCN, peptide, peptide-linker, and peptide-linker-citric acid constructs. (C) A5G81-PPCN is applied as a liquid that covers the wound bed and conforms to the wound edges before gelation, due to body temperature, within seconds. (D) The β-carotene lipid peroxidation inhibition assay shows improved antioxidant activity of the peptide-modified PPCN (n = 9) (*P < 0.05; **P < 0.01; ***P < 0.001).